Best way to leverage large email list

What’s the best way to leverage large email lists I gathered within certain niches for ecommerce?

What do you want out of leveraging your list?

Make quick cash? Long term cash? Sell the list or do a joint venture with an affiliate offer?

I’d build a close relationship with your readers… then send them mini commitment questions or CTAs and segment the list in terms of buckets and then sell them what they want?

^^ (Basically following Ryan Levesques ASK method)

Long term (building brands)